> Reporter: "Why is it hard to cure cancer?". Crowd: "Would there be enough of a financial incentive to do so? Seems like a prime startup opportunity!"
What you want to optimize for is the money amount that you make at some quantile of the probablity distribution of the profits; say, the profits that are guaranteed in the best, say, 3 %, 5 %, 10 % or even 20 % of all possible outcomes. With a probablity of 97 % (if you choose the best 3 % of the outcomes), you won't make sufficient money if you attempt to cure cancer to be worth the risk, so the financial incentive is not there.
TLDR: Financial incentives do matter, but work differently from how many people think that they are structured.
What you want to optimize for is the money amount that you make at some quantile of the probablity distribution of the profits; say, the profits that are guaranteed in the best, say, 3 %, 5 %, 10 % or even 20 % of all possible outcomes. With a probablity of 97 % (if you choose the best 3 % of the outcomes), you won't make sufficient money if you attempt to cure cancer to be worth the risk, so the financial incentive is not there.
TLDR: Financial incentives do matter, but work differently from how many people think that they are structured.