Yes, big difference. With B2 you’re just getting the raw storage, so all backup and restore operations have to be done through restic.
With their personal computer backup offering, there’s a web interface that you can use to download individual files from your backups, share files, or even have them mail you a flash drive containing your full backups.
Restic is good for storing files on computers you don't control because the private key doesn't get exposed. It also has features for snapshots and testing backups. You can select a percentage to test so if you have a slow internet connection you can get some piece of mind without having to download all your backup data.
Do you have access to your file via mobile access, sharing feature, etc.? https://www.backblaze.com/cloud-backup