I think it will be basically impossible to move away from von Neumann unless you control the entire stack, including OS and software. I don’t even think Apple could do it with Mac, because they are general purpose machines (for now at least). Maybe Apple could do it with iOS devices. Nintendo might be able to pull it off, though people trying port titles from other platforms may no longer try to do so. Because so many AAA titles go between XBox and PS, I don’t think Sony would try.
I'm not sure if Sony would want to make a system with a very unique architecture again. Devs complained about how hard it was to program PS2 games, and again with PS3. PS4 and 5 are practically PCs by comparison.
I don’t want to say that we’ll never see big architecture changes again but I think a company like Sony would want more confidence that they’d get real advantages. Cell wasn’t just unpopular with developers but also never delivered compelling performance; I suspect if they’d had a PC CPU and a Blu-ray player at the same price it would’ve sold identically.
Anyone trying this needs to figure out a decade-long schedule with points where something would be worth using for some reason so they don’t have to run the whole thing in a vacuum hoping it’ll be worth it at the end.
