My point is that for most people, the size savings of minification are going to be miniscule because most people are dealing with small JS files. Not only that but it makes debugging a much bigger pain. You start needing to generate and distribute map files, you can no longer easily observe or modify state from Dev console, etc.
I'm not completely opposed to minification. Distributing some self contained library like OpenCV.js? Minify away. But minifying everything even application files under active development just impedes developer velocity IMO for very little benefit. You shave off a couple hundred bytes in exchange for worse development/debugging and ostensibly faster page loads but realistically the same page loads.