Well the most significant difference [on macOS or Windows] is you must use a VM (by default Podman Machine) so there can be a Linux kernel to run the containers.

This is a significant limitation that you do not have when running on Linux. As I recall there are some other (related?) features that are not implemented on the macOS.

[edited to reflect that I misread the parent and thought they were specifically asking what was different on non-Linux platforms)