The line between media and real life is never really that wide. FWIW, I'm not sure how to feel about this - it seems juvenile and somewhat insensitive, but I have no desire to censor it.
But as a racial minority I'll say that media bleeds into real life plenty often - even in the most liberal, diverse parts of this country I'm either supposed to A) beat someone up with mad kung fu or B) be really good at math and talk nerdy. There's a compounding and cyclical effect in media portrayals of anything - it begets more skewed perceptions which begets more skewed portrayals.
Media and real life reinforce each other - fiction is not consequence-free.
It's easy to sit back and ask everyone to just take the joke in good humor - until you end up on the wrong end of it. I'm not a woman, nor a sex worker, nor someone resembling Larry, but I've seen enough of these issues to know that when complaints like these arise, there's most often a valid rhyme and reason behind it.
Do we remember the last time that exact phrase came up as a topic on HN?