In this time period, there are many people who are eager to cause mass suffering, murder, sabotage, and dissolution of civilization. With advances in technological organization, there is an increasing potential for coordinated autonomous attacks against infrastructure, essential services, groups, and individual persons in multiple theaters concurrently.

It would be neigh impossible to defend against 100k flying drones wielding cow-knockers programmed to swarm, loiter, break windows, and kill humans. Such could be dispensed by purpose-built intermodal containers, moved by ordinary freight logistics to attack multiple population centers in a simultaneous attack.

Code and binaries are shipped to 10's of millions of servers by internal configuration management tools. Take Meta, Google, or Microsoft and turn them into AI exploit and worm fabrication at scale. While it may happen for only an hour or 2, there's quite a bit that could happen and the possibility of advanced persistent threats is real.

Target a demographic to alter their filter bubble to persuade them to engage in mass-casualty terrorism.

Hate group applies AI to create a designer virus lethal to particular a demographic.

Subtly disable water treatment facilities with an autonomous, stuxnet-like attack.