The last time I used a numberpad was to play Civilisation in the 90s, so I don't really miss it. I hate moving my hands too far from the home row, and it's now a few inches less travel to my mouse when I need it so that's a positive. If I ever had to manually enter a bunch of numbers in a spreadsheet or something I'd either automate it or re-evaluate my life choices.
>The last time I used a numberpad was to play Civilisation in the 90s
Ay! another civ 2 fan! I agree it's painful to play that game without a numpad. I also used it with some tactical shooters to radio compass directions to my team. 'Enemy spotted south south east!' It came in handy.