There is one problem that worries me, 1.4 came out with a known (for few RC's and 2-3 releases before) regression that makes Photoshop CS5 unusable - not sure about older ones too but it might also be the case :(
latest test entry is mentioning that - i also encountered it - before i used last stable from fedora - that worked well. I would have to dig buzilla for reports, but i wouldnt be surprised if there are no reports for it.
Yeah, the chances of a regression being fixed increase massively if you do a regression test to bisect the offending commit and file a bug on Bugzilla.
I tried using CrossOver to run Office 2007 a year ago, and while it basically worked I found it was just as good if not better to run Windows in VirtualBox (and I don't even have VM instructions on my processor).
True, though you can still use VMWare Converter [1] image your OEM install and then run it in a vm. You just get the constant reminders that Windows is not authentic and you should activate it.
I haven't looked at it lately, but I think one reason I used to run Wine instead of a VM was that Wine gives better 3d support for games. I even ran EVE for a while, before I realized that Wine wasn't able to draw the lasers pew-pewing from my ship, which made things kind of boring.
Now to go search and see if Wine 1.4 works on FreeBSD at all.
The DIB engine is something I've been anxiously looking forward to for a long time now. It makes productivity suites.. work. For me the biggest thing was not being able to run Sonar and many VST plugins under Wine. Now I'm waiting for them to figure out Jack audio output again, and then we get a new version of KX Studio ( http://kxstudio.sourceforge.net ) with realtime patches. Other than the GUI problems which are probably fixed by Wine 1.4, this setup gives stellar performance compared to anything you can get on Windows or OSX.
Well, it was 1360 yesterdays: http://news.ycombinator.com/item?id=220164