I've had it both ways, hopping over the Atlantic a few times, working from both office, hotel, apartments and actual home plus the occasional conference or weekend at friends. Eternally grateful for my laptop back then, actually bought one a bit bigger than what the company had me use (and, well, a Mac instead of a Vaio).

Now, I'm a sessile work-at-home startup guy who's really happy with a Linux tower and several displays connected. I've gone so far as to miss the ubiquitous color beige of ages past.