And most old games are run within emulators (even something like dosbox) anyway. All you can do is infect that.
But in those days viruses were truly rampant. I have many Amiga disks with viruses on them. As my Amiga had no hard drive and only 1 floppy there wasn't many places for them to go though.
see https://news.ycombinator.com/item?id=34101899