I usually get ~300ms ping from my home to us-east-1. You can absolutely feel the latency, especially on SPAs that performs many small xhr sequentially which compounds the latency even more. Apps that felt almost instant when used in network with <10ms latency are suddenly felt pretty sluggish.
Some of my worst experience was being forced to use SFTP to transfer thousands of small files to a server in us-east-1, which can take hours due to latency alone compared to transferring the same set of files using rsync / compressed archive which finish in minutes, and using RDP to access a remote windows machine behind a VPN, then run putty there to access a Linux server (the VPN only allows RDP traffics), and then I need to transfer thousands of files to the Linux server as well (my solution was to punch a hole through their shitty VPN via an intermediary bastion host I fully control, which allows me to use rsync).
Some of my worst experience was being forced to use SFTP to transfer thousands of small files to a server in us-east-1, which can take hours due to latency alone compared to transferring the same set of files using rsync / compressed archive which finish in minutes, and using RDP to access a remote windows machine behind a VPN, then run putty there to access a Linux server (the VPN only allows RDP traffics), and then I need to transfer thousands of files to the Linux server as well (my solution was to punch a hole through their shitty VPN via an intermediary bastion host I fully control, which allows me to use rsync).