Yes, what possible moral problems could there be from using the one substance in the universe that we know produces sentience to build machines to play Pong?
I don't think the Luddite philosophy applies in this case, I think OP may have been speaking about the morality or ethics of growing a brain in a dish? Luddism is more about when the capitalist class steals worker productivity gains for themselves, and is a pretty valid philosophy for today, when the capitalists are trying to replace thinking humans wholesale with computer AI.
TIL what a luddite is: apparently they started in 1811 and were named after Ned Ludd, a textile worker in England. So what was the characteristic called in 1810?
Maybe the concept is not much older than that. Luddite implies resistance to technological change and the disruptive consequences of those changes. Before the early modern era, you might go your whole life never encountering/seeing/being replaced by a disruptive new technology. If you've never experienced repeated new changes of that sort you could hardly develop a dislike for them.
According to who you're replying to, they're actually 10,000 years old, and complain about scientific research, rather than about being pushed out of their textile jobs by machinery.
