I tried the Blizzard launcher several times with Wine, but almost no success. Qemu with GPU pass-through works much better for me. I use a decommissioned GPU from my son for Diablo 2R. IO is a bit slower, because the IOMMU groups of my Asus board prevent SSD pass-through of the second SSD. The first SSD is in its own IOMMU group, but the second is in the same group as the network, which I need for Debian.