I'm a big proponent of resumes that show personality and break the mold. Do a search for examples of designer resumes and you'll see how much of a person can be expressed through just the design choices, while still expressing all of the relevant content that you expect.

I've heard from resume screeners that a lot of them are told to throw out anything that doesn't match one of the standard formats, or that has color. But do you want to work for a company that imposes such arbitrary, or at the very least stale, rules from the get-go? I think the corporations (generally larger ones) that have these kinds of restrictions could be missing out on the most creative and self-driven employees.