I have no experience with NextDNS, but with PiHole I can say it has been very "set and forget". Logged into the router, set the DNS server IP. Then into Windows to disable IPv6. Now it just runs in the background quietly for years. It can be set up to do updates automatically as well if desired.
I have occasionally disabled it, thinking it may have been the cause of some internet trouble, but so far that's never been true.
> I have occasionally disabled it, thinking it may have been the cause of some internet trouble, but so far that's never been true.
I hear people say this about PiHole all the time but I have a hard time believing it. I run into a couple sites a week that don't work right with Firefox standard privacy settings and UBlock Origin. I certainly don't want to add another troubleshooting step when web sites break.
I have occasionally disabled it, thinking it may have been the cause of some internet trouble, but so far that's never been true.