> So, without that, the best you could do would be to find a drug that is approved for something else that can be used off label.
Xylazine has a very rapid onset and a short half-life. So, as it can take >40 minutes for orally-administered drugs to be absorbed, there are really only two options that _might_ be legal and effective.
1) Administer an FDA-approved alpha-2 antagonist intravenously. There are no good options here. AFAIK, the only FDA-approved alpha-2 antagonist that's available as an intravenous injection is Thorazine -- and it does a hell of a lot besides counteract alpha-2 adrenoceptor activation. It's also an alpha-1 antagonist, dopamine antagonist, serotonin antagonist, and more. This likely makes it a little bit unpredictable in drug overdose scenarios.
2) Sidestep FDA approval with a fast-acting yohimbine nasal spray, administered as a "dietary supplement."
The FDA process is a terrible roadblock in situations like this. Intravenous atipamezole, which would be much better than either of the two options above, is available for veterinary use, but would be totally illegal for use in humans. (Like xylazine itself!)
Xylazine has a very rapid onset and a short half-life. So, as it can take >40 minutes for orally-administered drugs to be absorbed, there are really only two options that _might_ be legal and effective.
1) Administer an FDA-approved alpha-2 antagonist intravenously. There are no good options here. AFAIK, the only FDA-approved alpha-2 antagonist that's available as an intravenous injection is Thorazine -- and it does a hell of a lot besides counteract alpha-2 adrenoceptor activation. It's also an alpha-1 antagonist, dopamine antagonist, serotonin antagonist, and more. This likely makes it a little bit unpredictable in drug overdose scenarios.
2) Sidestep FDA approval with a fast-acting yohimbine nasal spray, administered as a "dietary supplement."
The FDA process is a terrible roadblock in situations like this. Intravenous atipamezole, which would be much better than either of the two options above, is available for veterinary use, but would be totally illegal for use in humans. (Like xylazine itself!)