UPenn's CIS341[1] is pretty nice. It uses a bottom-up approach, where assignments start with a 64-bit integer-only x64 simulator, then goes up to compiling LLVM IR to x64, then compiling the lecturer's language ('Oat') into LLVM IR, and then optimisations like dead code elimination, register allocation, variable substitution, etc.

[1]: https://www.seas.upenn.edu/~cis3410/current/