>As many have mentioned, there is a large subset of the user base that uses Python for applied purposes in unrelated fields that couldn’t care less about more granular aspects of optimization.

Nobody cares about this that much. Even a straight up software developer in python doesn't care. The interpreter is so slow that most optimization tricks are irrelevant to the overall bottleneck. Really optimizing python involves the FFI and using C or C++, which is a whole different ball game.

For the average python developer (not a data scientist) most frameworks have already done this for you.