There are autosomal dominate conditions that have a comorbidity of ADHD. hEDS for example. The genetic cause for hEDS hasn’t been discovered but there are candidate genes. Clearly given the higher likelihood of having ADHD with hEDS the hEDS genes should show up in ADHD genetic surveys. But diagnosis for ADHD and hEDS are very noisy so it’s still hard to find.
Right, and I frankly don’t see that improving much sooner without cheaper and more objective diagnostic methods. UW eye dilation diagnosis is one example of a bright spot that could help affordably and reliably diagnose. The current diagnostic system is flawed and biased around unequal access to care.
My hope is the increasing availability of WGS data allows for citizen scientists to work around the institutions. hEDS being a good example, the HEDGE study has too strict of entry requirements and thus misses the much more common but less severe types of hEDS. This is possibly by design as maintaining a rare disease classification helps with funding. They also work crazy slow for seemingly no reason besides the obvious that more time means more funding.
Recently some more advanced machine learning techniques have been ported for use in DNA population studies so I’m hopeful that’ll improve research quality.
