I haven't used AutoKey personally, but it's quite capable and generally "just" a Python library that also happens to ship with its own optional editor (https://autokey.github.io/autokey/_images/AutoKey_Scripting....).

Keysharp / AHK_X11 on the other hand ship their own runtimes that will be / are compatible with the actual programming language AutoHotkey v2 / v1 and thus cannot be used in conjunction with other languages, apart from shell invocation. For a detailed feature comparison with AutoKey you will have to research this yourself, but there's at least one feature which is exclusive to AHK_X11 right now, and that is accessibility-related commands such as ControlClick or WinGetText.

AHH that's very interesting and useful. I'll definitely check them out.