I mean, comedy is heavily reliant on the element of surprise. Being set up to expect a particular story progression and then having that expectation flipped on its head is funny, when executed with an appropriate sense of timing. The more subconscious your expectations, the funnier it is when they are subverted. The challenge, which Rick and Morty rises to unusually well, is continuing to surprise the audience in unusual ways. Any formula will get boring after a while, including "do the opposite of normal tropes".

Speaking of surprise, your wording implies you haven't seen the show, in which case you shouldn't be reading this thread.