Most is details you don't need. However knowing how a function call works, what kind of branching is available and how to do basic operations with collections (arrays or more) at the assembly level will allow you to write more efficient code in higher level languages.

It is fundamental knowledge, but you can skip it thanks to higher levels of abstraction.

In the end everything is just bunch of ones and zeroes and clever hardware architectures.

Nand2tetris is great source for figuring out whether this is something you want to get in to.