I don't have any of the extended filters, but it is a small size reduction with the default load:
$ ./pdfsizeopt next-level-database-techniques-for-developers.pdf ... info: generated object stream of 7399 bytes in 224 objects (9%) info: generated 387518 bytes (89%) $ stat -c '%s %n' next*.pdf 435483 next-level-database-techniques-for-developers.pdf 387518 next-level-database-techniques-for-developers.pso.pdf
I don't have any of the extended filters, but it is a small size reduction with the default load: