I don’t doubt that the problem is a tough one to solve. This is (partly) why I suggest offering a marketplace for filters, and so a reward for those who crack the problem. Of course there are always going to be some people who which deploying any kind of filter is just too much work. There were always some for whom editing a .killfile was too much.
I expect this would end up like Netflix's algorithm bounty. It turned out no one could do much better than Netflix's own engineers. Twitter already had a system that worked in the form of sharable blocklists, but they hobbled and eventually removed it for some reason.
I could easily build my own just by iterating through the follower lists of prominent objectionable people to block them if Twitter didn't prevent it.
