Seconded. I'm doing a radically different thing from Rob's focus on niche web apps, so a lot of his advice didn't directly apply. But as someone taking the independent/bootstrapper approach to starting a software company, I still got quite a lot out of the book.
And I'll recommend this one then: http://www.mixergy.com (I am quite active over email with the host and have arranged several of the interviews - Morten Lund and John Robb come to mind)
I'd strongly recommend the podcast as well: http://www.startupsfortherestofus.com/