What about doing the same thing, but fuzzing a few pixels from each edge to avoid pixel distance matching? You could even make the edges just plain black for a few pixels from each edge. The human eye would be able to complete the image (it would just look like it has black bars), but I'm guessing it would be enough to prevent a simple algorithmic solution.
Edit: This is essentially the same idea as the iron fence posted above.
Edit: This is essentially the same idea as the iron fence posted above.