Anything David Sinclair has endorsed should be considered with at least double the normal skeptical scrutiny.

I don't think he _endorsed_ rapamycin or metformin. If he endorsed anything, I'd say it was NMN.

Everything people like Sinclair state should be taken with a grain of salt (as even his peers say he's guilty of making excessive claims) but it's forward-thinkers who change the world, not people following others' steps and afraid to take peek outside their box.

Maybe the guy will achieve something real in the field and maybe it'll be the next guy. No way to know. But I'm far from dismissing someone just because their opinions are not in line with popular knowledge. Boltzmann, Galileo, Copernicus and Wright brothers were discredited or ridiculed.

Lol, why do say that? I had the same impression of him.

It appears that people fall for his niceness is my theory about him. And no doubt he is a nice guy. It's just that his explanations lacked the rigor I generally look for.

A lot of his earlier work with resveratrol was extremely sloppy and it fell apart in time. I believe it's a lot of what gained him earlier popularity, and has effectively been debunked to a very large degree.