I have 6 neighbors in my cul-de-sac. The Amazon truck probably visits 5 out of 7 days a week. I never worried about whether my Amazon purchases were wasteful based on trucks and fuel. They were quite wasteful in the sense that I bought a lot of cheap crap I didn't actually need.
This is the worst thing about it. Holding something and deciding if it's worth your money is a much longer process than clicking "buy now", and you've probably don't even remember doing it when the goods show up in front of your door.
Amazon day is probably similar. There's a designated day of the week where they deliver everything I've ordered that week.
I don't have hard data, but it makes sense that if more than one person in my building/block/etc does the same (thus sharing the same delivery vehicle), it's probably less driving/gas overall.
You have to be very disciplined to get as efficient with Amazon. It's probably not really possible.