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> mean that it is impossible for an extremely highly conserved component of spike protein to jump to a new configuration, that at the same time escapes antibody response for the conserved region and maintains any degree of fitness in the wild.

See this is exactly the sort of quantification I was asking for from the beginning (albeit still somewhat vague). Others in the thread have already answered most of my questions (read the other threads if you like) but you just kept talking past them until now. I appreciate you taking the time to respond.

> walk through the door and explore the field yourself. It's fascinating

That is precisely what I am trying to do here because I do find it fascinating as well. I have to be allowed to ask questions (even stupid ones) and I do those primarily in discussion forums like HN.




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