I'm not sure I see a huge advantage that can be obtained via tight integration that you can't get by simply clicking "Save" and then ALT-Tab-ing to your Python script/notebook/whatever and re-running it, targeted at the file you just saved. If you're feeling really feisty, see about integrating a file watch program to do it as soon as you save. It's not like the editor is going to be using a pandas layout internally it can just pass to Python without marshaling.

At some point (maybe version 3), I'd like to integrate Python to allow users to make their own commands. This would give them access to entire rows, columns, ranges, etc.