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It's an Orthopoxvirus [1] [2] and is easy to target and kill. We've already eliminated one of the viruses in the family: Smallpox-causing Variola.

Also notable, it's a doubly stranded DNA virus, so it will mutate less frequently than other virus families, such as ssDNA and RNA viruses.

Patients will undoubtably be monitored closely. That said, we do need to be extremely careful. Wherever it may have originated, Covid should have hopefully instilled caution and respect for safety protocols.

[1] https://journals.lww.com/journalacs/Abstract/2020/04000/Nove...

[2] https://en.wikipedia.org/wiki/Orthopoxvirus




It wouldn't happen to be a monkeypox virus, would it?


No. CF33 appears to be a chimera of nine viruses: six strains of VACV, cowpox, rabbitpox, and raccoonpox created in monkey cells[1].

Seems to be mostly vaccinia (VACV)[2][3].

[1] https://pubmed.ncbi.nlm.nih.gov/29988502/ page 18

[2] https://www.cell.com/molecular-therapy-family/methods/fullte...

[3] https://www.nature.com/articles/s41417-019-0114-x


Nice zombie reference. But for those curious,

> CF33, and its genetically modified variants (CF33-hNIS-ΔF14.5L and CF33-hNIS-antiPDL1). The creation of CF33 and its sequenced genome has been previously described (11). Briefly, recombination among 9 different species/strains of orthopoxviruses [Cowpox (Brighton), raccoonpox (Herman), rabbitpox (Utrecht), vaccinia virus (Western Reserve), International Health Department, Elstree, and VACV strains Ankara (AS)] resulted in a chimeric orthopoxvirus, CF33, which did not previously exist in nature. This virus has been found to be highly specific for infection, replication within, and killing of breast cancer and pancreatic cancer (11, 12).

From

https://www.sciencedirect.com/science/article/am/pii/S107275...




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