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> how does that change anything?

If you don't know how many tickets the lottery sells you cannot estimate the probability of winning it. Your assumption that universe ends exactly as far away form us as we can see is absurd, so I pointed it out.

> Proteins are not genetic code.

Proteins are generated from the genetic code, and it's the genetic code that evolves and gets inherited over generations not proteins. Proteins are just an expression of this inherited and mutated code. So it makes more sense to focus on the code and not on the result. And the relationship isn't 1:1. See also "Kolmogorov complexity".

For 1 example - Pi is infinite and non-periodic. But the algorithm to generate Pi to an arbitrary digit is quite simple and short.

> Let's say there are 4 viable titin alternatives.

There's more than that in every single human being. And it changes through life.

> The titin gene (TTN), with its 364 exons, encodes the largest human protein. It gives rise to a dizzying array of alternatively spliced isoforms differentially expressed in various skeletal muscles, heart, and in development.

https://jamanetwork.com/journals/jamaneurology/article-abstr...

We focus on the ones that lead to sickness, but there are also many that don't.

> Do you think there are other universes?

No. I'm talking about the hypothetical situation in which titin evolved differently. In that case you would think that this version of titin was the only version possible and you would calculate the probability basing on that instead. Yet it's obviously wrong.

> "materialism of the gaps"

It's you who assumes that God must have made it because you don't understand how it could have happened. Depsite your false assumptions about the probability:

1. titin can only works if it's exactly as is (despite the fact there are many working variants present in every single homo sapiens, not to mention inter-species variants)

2. titin could have only evolved in the part of universe that we can see (despite the fact it's obvious there's more universe than that - see gravity distribution)

3. evolution works on proteins directly by changing them 1 particle at a time (despite the fact evolution works on genetic code and not 1 pair at a time)

These assumptions are all false as I've shown above, hence your estimation is useless. It has nothing to do with alternative universes or "gaps".




I’m going to have to move this discussion to a substack newsletter. There are good responses to all your objections, but a hacker news thread isn’t the place. I don’t think you appreciate the difficulty of unlocking the precise proteins that are needed for life, and pointing to a “code” that generates them just makes the situation more miraculous, not less. I’ll drop a comment here when I get a substack newsletter going on this subject. I will welcome your comments and input, since it is clear you are passionate, willing to do research, and eager to find objections to theism.




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