If anything that got worse as clocks got higher, but there is more abstraction in terms of things like tooling to help you get around that. An auto-router from the 80's wouldn't stand a chance to route a modern computer motherboard, essentially every trace is a transmission line, so while nominally it is all digital you are deal with the analog parasitic components all of the time unless you have tooling that will take care of that for you.
You could build a 2 MHz computer on a breadboard and expect it to work. The main analog parts in old computers were at the periphery, the sound DAC, the video drivers (the hardware part of that), TV modulator (usually a module to allow for easy NTSC/PAL/SECAM adaptations), joystick interface (ADC, or switches, depending on the model), cassette tape interface and so on.
You are right about how much harder higher clocks made things. PC mother boards got stuck at 33MHz for the longest time even though 50MHz processors were available. It took Intel coming out with the 486DX2 (50MHz inside the chip, 25MHz on the board) to get things moving again.
A key transition was moving from the 1 and 2 layer printed circuit boards of 1970s e cheap 1980s computers to 4 layers like in the IBM PC and Apple Macintosh. The difference a ground and power plane makes in the waveforms is simply amazing.
You could build a 2 MHz computer on a breadboard and expect it to work. The main analog parts in old computers were at the periphery, the sound DAC, the video drivers (the hardware part of that), TV modulator (usually a module to allow for easy NTSC/PAL/SECAM adaptations), joystick interface (ADC, or switches, depending on the model), cassette tape interface and so on.