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Nothing works against p-values than a large sample, no matter what the power analysis says.-Folk Science Wisdom 101



Shrinking would work to some extent, by borrowing information from other variables. This is better done in a Bayesian context with multilevel models.

Also weakly informative priors, which have regularizing effects.

Actually these two things are a big focus area of Stan, which is the probabilistic programming language built by the group which writes that blog.




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