An interesting company in this space is LifeMine Therapeutics. My understanding is that they have a large collection of fungi genomes. They apply bioinformatics techniques to search for genes encoding metabolic pathways that produce biologically active molecules. Fungi metabolism produces some truly wild chemicals, which, as the article mentions, include some of the most important medicines we have ever discovered. Penicillin is the classic example.

Personally, I was totally enthralled learning about this approach. Using artificial brains to scour the life essence of fungi to discover ancient, mysterious compounds that heal disease. It's like a scifi/fantasy subplot that gets cut because it sounds strained.

https://lifeminetx.com/