Got my second Moderna dose in september and was about to get the booster but instead I got omicron positive. Absolutely asymptimatic and quite an accidental discovery, got tested randomly for no reason. After the infection goes away would it be recommended to get the Moderna booster right away or wait for some time?
> After the infection goes away would it be recommended to get the Moderna booster right away or wait for some time?
Honestly, if it were me I'd probably wait. If the goal is to maximize immunity, it seems like it would be better to boost when it's possible your immunity from your infection might have waned. Plus, by that time they may have vaccines better tailored to the circulating variants.
My second Modera was in August and I was sick for a week with Omicron a few weeks ago. Symptomatic cases where I live are asked to confirm their status by PCR.
Where I live, the answer is ask your doctor or after three months. Also where I live there are consequences for not being boosted or recovered and the rules change with little notice. It depends what you are optimising for.
If one were to assume the protection afforded from recovering is at least similar to a booster shot, then I would presume whatever the latest vaccine spacing is considered best.
I don't know what evidence the three months is based on but a recent TWIV episode talked about "Effectiveness of COVID-19 booster vaccines against covid-19 related symptoms, hospitalisation and death in England"[1] and "COVID-19 Cases and Hospitalizations by COVID-19 Vaccination Status and Previous COVID-19 Diagnosis — California and New York, May–November 2021"[2].
Comparing ~6 month to ~9 month spacing, the booster article looking at Delta had this to say:
"The improved vaccine effectiveness with a longer interval between dose 2 and the booster suggests that there will be some benefit in delaying booster doses. Nevertheless, this improvement was only small and has to be balanced with the reduced protection among those that have received just two doses (where protection may have waned), compared to protection from the booster even with a relatively short interval. This finding was also similar to the reduced effectiveness among those that had a shorter interval between dose 1 and 2. Furthermore, similar findings are also seen with history of prior infection whereby a longer interval between infection and vaccination was associated with increased protection."
