This intuitively makes sense. A lot of you are noting that a sedentary office environment is foreign to a species that has spent most of it time - prior to the last several thousand years - moving in search of food, and use that to critique the article. But I don't see how standing stationarily in one place is any less foreign to the human experience.

While standing might help work additional core muscles, it is not working large leg muscles that are crucial to circulation at the same time that it's increasing stress to the circulatory system.

(For those that don't know, muscle movement is important to the return of blood to the heart (http://en.wikipedia.org/wiki/Venous_return_curve) in addition to lymphatic circulation (your _other_ circulatory system - http://en.wikipedia.org/wiki/Lymph#Lymphatic_circulation) )

I could see persistent standing w/o movement stressing arteries because of greater hydrostatic pressure in your legs and increased load on the left ventricle of the heart.