It's not like those jokes are the core of Life of Brian. They're incidental, part of the comedy culture of the time. It is impossible for comedy to be truly timeless. If someone was making a movie like Life of Brian today, some of the jokes would be different, sure. But that's true of anything.
right because there's no examples of modern comedy that uses trans people as the butt of their jokes... None at all. Certainly no massively successful Netflix standup specials or anything like that.