I guess for the most part I am not using any the clients - I just point my home router DNS, my Android operating system DNS, and any browsers that might bypass. I erroneously assumed those profiles could only be chosen if the client was being used but it looks like I may actually be able to create different profiles and then still just point the devices network settings to the correct IP. Too bad for "LinkedIP" they dont let you manually specify (it looks like you have to click the button while you are on a machine using the network you want to link)
Hmm yeah I was actually also just pointing IP's for a good while[0] until my mobile ISP (4G router) decided to not allow custom DNS to be used, after which I installed the NextDNS app (with DoH or whatever is default) and got rid of that restriction.
[0] I remember I had a cronjob calling a particular custom NextDNS URL regularly, through which I'd like to remember I was able to choose a specific profile
