Huh, I've been talking to my therapist about my antidepressants not being terribly effective anymore. Is there a way to sign up for a clinical trial for this?
Or you could look into psychedelic medicine. On the legal side, ketamine has helped a lot of people with treatment resistant depression. You could also look into participating in clinical trials of MDMA or psilocybin. The clinical trial results for those medicines are phenomenal, too.