It's possible I underestimate, but I have worked in all the relevant fields of simulation, ~20 years of running various simulations on large HPC, built the largest instance of folding@home using idle cycles inside google data centers, published papers simulating proteins, developed infrastructure to process the voluminous data, etc, etc. Quantum computing remains fantasy (in terms of being useful for science).
It's unlikely even if we improved computing hardware many orders of magnitude beyond all reasonable predictions, that the calculations would be able to simulate all the necessary details; most of our simulations now are based on many approximations due to hardware limitations.
As to the question of "what level of fidelity is required to turn a FASTQ of somebody's genome into an accurate model of the resulting human, with some sort of realistic environment also provided", that's so far beyond what is even remotely comprehensible it's not worth speculating about in terms of science fact; it's just fiction.
It's unlikely even if we improved computing hardware many orders of magnitude beyond all reasonable predictions, that the calculations would be able to simulate all the necessary details; most of our simulations now are based on many approximations due to hardware limitations.
As to the question of "what level of fidelity is required to turn a FASTQ of somebody's genome into an accurate model of the resulting human, with some sort of realistic environment also provided", that's so far beyond what is even remotely comprehensible it's not worth speculating about in terms of science fact; it's just fiction.