One of the other comment threads indicates that the data, that you need to do that kind of annotation of the sequence, is to some extent available for home use as well: https://news.ycombinator.com/item?id=29695449
I'm really hoping someone will work on an open source "23andme@home" solution that ties all this together in an accessible way.
Years ago I used Ancestry, then requested the .txt file and asked them to delete it from their records. Uploaded it to run a report at https://promethease.com/ that cross-references your SNPs against the existing body of genetic research.
The results have been pretty astounding. I found markers that pointed to poor response to a specific blood thinner my grandfather was put on before he passed. Currently I'm researching the cluster of Bipolar / ADHD / SAD symptoms I experience that all seem to trace back to a certain genotype of circadian rhythm genes I have (thank you, Sci Hub). To boot, some of the studies I've come across have been done on Han Chinese populations that match my descendance.
Perhaps going too far down this rabbit hole poses a self-diagnosis risk, but the correlations to my family history and my own life experience working with doctors to diagnose and treat symptoms are pretty undeniable. And given that your run-of-the-mill psychiatrist is going to treat you off of a DSM checklist, I feel much more confident knowing there have been genomic studies to back things up, since my doctor isn't up to date on this research, and finding one that would be will be difficult and expensive. I've shared the papers with my doc and he's been supportive, sometimes I feel like I should be getting a discount on services rendered.
Self-diagnosing is not the problem it is made out to be - I live with my symptoms 24/7, doctor sees me for 5 minutes. The amount of times doctors have missed fairly clear sign of trouble in my family is disturbingly high. A simple procedure, done in time, would have saved two people I know.
Unfortunately our educational system teaches you about mitochondrion, but not the practical difference between ibuprophene and paracetomol, or CRP.
That's Prometheus, no? They got acquired however, but prior to that you could upload data anonymously and then browse the analysis. It was very rough though, just linking sequences to risk, but a lot of it was inconclusive.
