A decade ago there were promises of huge advances in treating diseases based on knowledge related to the human genome project, but then gene therapy kind of fizzled out. I'm wondering if all the latest medical breakthrough news is just the latest round of similarly overhyped findings, or if this is something else.

Specifically, now that basic gene replacement -- perhaps we could call that a naive application of the new genetic knowledge -- has generally been ruled out, scientists have been looking for more subtle ways of applying what they learned in the last two decades wrt genetics/molecular biology and it is starting to bear fruit. INAD, but if anyone has insight into whether this describes what has been happening lately, I'm curious to hear.