If you want maximum possible accuracy for FP computation, you need to pay the performance price that denormals incur. In many cases, that will likely be a long running computation where responsiveness from a user-perspective and/or meeting realtime deadlines is not an issue. Any time "I want the best possible answer that we can compute", you should leave denormals enabled.
By contrast, in media software (audio and/or video) denormals getting flushed to zero is frequently necessary to meet performance goals, and ultimately has no impact on the result. It's quite common for several audio FX (notably reverb) to generate denormals as the audio fades out, but those values are so far below the physical noise floor that it makes no difference to flush them to zero.
By contrast, in media software (audio and/or video) denormals getting flushed to zero is frequently necessary to meet performance goals, and ultimately has no impact on the result. It's quite common for several audio FX (notably reverb) to generate denormals as the audio fades out, but those values are so far below the physical noise floor that it makes no difference to flush them to zero.