Anti-androgens and GnRH agonists like Spironolactone, Cyproterone Acetate, Goserelin Acetate, Bicalutamide to name a few. Also to a lesser extent 5α-reductase inhibitors like finasteride (Propecia) which only suppress the more potent dihydrotestosterone.
All of these work by suppressing androgen production (mostly testosterone and dihydrotestosterone), this will suppress most of the male libido. While they don't remove the ability to get an erection if you try, they will prevent the hormonal lead-up that would normally lead to one. You'll likely stop thinking about sex entirely, there won't be much of a drive. GnRH agonists like Goserelin Acetate (zolodex) are highly effective, spironolactone is very weak and a potent diuretic.
On the downside... an adult human body expects to have a dominant sex hormone, either testosterone or oestrogen, and a lot of things hang off this. For one, initial breast growth is inhibited by testosterone, so you will likely develop gynecomastia (unwanted breast development). Your body hair will reduce, though facial hair is mostly unaffected, and your skin will become softer. Long term you are at increased risk of developing osteoporosis, and your testes and genitals will shrink. Sperm count and viability will reduce, though for some people this is recoverable.
It will halt any male pattern baldness though.
Most of these drugs are used for treatment of prostate and testicular cancer, so their effects are well known.
Do you happen to be a doctor/scientist? I’ve had an unbelievable experience which I’m looking for a scientific explanation to / trying to replicate, but I’d rather not share publicly. Is there a way to get in contact with you outside hn?
I'd recommend that any man thinking about taking these for ANY REASON (including transitioning) have his T levels measured first - Low T is more likely to cause adverse behaviors and mental issues than high T (contrary to the "roid rage" hypothesis of "male toxicity" BS).
Roid rage can be a thing but it's more complex than simply having too much T - it's a dynamical system so it's very much like getting a sugar high and then insulin shock afterwards: you will rebound from high T intake to very low intake and that better explains most of roid rage.
Where I live high doses of cyproterone acetate have been used for chemical castration (>200mg), but at these levels there's a chance of developing benign brain tumours, so they try not to do this.
I think zolodex is also used in this manner, and it's more effective since it's a long-lasting implant rather than a daily pill.
In both cases they're not 100% effective, different people respond differently.
There is a widely circulated rumor that in the Romanian army they used to put a small quantity of bromide (sodium or potassium? don't know) in the evening tea; it is not supposed to prevent an erection, but total lack of sexual desire. This was 30-40 years ago, I was not able to find any official documents related to that, but any men over 50 years old is telling that story.
In Finnish army this was in the tasteless dessert pudding they served at every meal. The theory was frequently tested and proven to be true. You would get annoying and embarrassing morning wood if you skipped the dessert.
So many come to mind, I could write a whole article about it.
None of them have an acceptable side effect profile, many of them can potentially cause persistent inability to have sex to the point where not even megadoses of pde5 inhibitors help.
I strongly advise against ever taking SSRI or 5ari for this purpose. They are now known to cause persistent ED in susceptible individuals.
For the interested: You can prevent ejaculation (i.e. there is a loss of seminal emission, but not orgasm) using silodosin. It can be used as a male contraceptive. Low doses tend to work, but I recommend testing it before the real action[1]. You will still have orgasm, but without ejaculation. Be cautious though, because it is not without side-effects. Do your research!
It is funny how there is not much of a mention of this substance for this purpose, even though it is indeed effective for it. A male contraceptive pill.
[1] Do not forget about the importance of dose, onset of action, duration of action, stomach content, and so forth.
Medical curiosity and some research. My friend and I got the idea, discussed it, and he decided that he should put it to a test. It worked! He has done a lot of experiments on himself.
> Would it enable the ability of having unlimited orgasms?
This is an interesting question. I will ask my friend to do some research on that. I am not sure that ejaculation is necessary for the compounds responsible for the longer refractory period to be released.
Drugs that lower testosterone will typically accomplish that outcome. Men that go through prostate cancer treatment for example will often have erectile dysfunction (due to hormone therapy targeting testosterone - androgen deprivation therapy).
(Serious question)