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That seems very unlikely. If a variant evolves that has significant evasion of the vaccines, then we should be able to retool the mRNA vaccines quickly. And T-cell response is more robust to antigenic drift than the antibody response, though not as well studied. See [1] for a very detailed investigation into antigenic drift and vaccine evasion.

[1]: https://www.nature.com/articles/s41579-021-00573-0




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