I don't use ProTools, I use Bitwig Studio which is a full blown DAW with native linux support. There's also Ardour and Reaper, so linux has plenty of DAWs to choose from. Also as I have mentioned in another comment - all VSTs that I need work just fine with wine/yabridge.

I don't use Adobe's stuff either, but I know other people run Photoshop on wine, I just don't know what issues they're facing.