While its goals are a bit different from confidential computing, people saying "no" here have apparently never heard of the Xbox One. More generally, securing a device against its physical owner is notoriously difficult. Tony Chen gave a talk about how the Xbox One was secured against physical attack: https://www.youtube.com/watch?v=U7VwtOrwceo
Chen makes it very clear that their threat model only includes attacks costing less than the attach rate of the system (about $600). He doesn't consider it an achievable goal in the general case.
