The antibody-dependent enhancement (ADE) is what scares me the most.
While our vaccines were in development, Dr. Fauci described causing ADE as "the worst possible thing you could do" [1] and that you could get a feel for it with animal models, which would be interspersed with human trials. Interspersing the animal models seems incredibly risky to me, and to my knowledge we haven't seen those studies with the vaccines currently in production.
So far, the data does not seem to indicate that we're in big trouble yet -- the vaccines are still effectively preventing death -- but seeing the breakthrough cases gives me pause. I would appreciate if the "establishment" would circle back and address the risk of ADE. Even if it is very unlikely, what is the game plan if new breakthrough strains do start causing this type of response?
Because right now, it seems to me that if humanity puts all its eggs in the vaccine basket, and then ADE occurs with a breakthrough strain, then there is potential for an enormous catastrophe.
While our vaccines were in development, Dr. Fauci described causing ADE as "the worst possible thing you could do" [1] and that you could get a feel for it with animal models, which would be interspersed with human trials. Interspersing the animal models seems incredibly risky to me, and to my knowledge we haven't seen those studies with the vaccines currently in production.
So far, the data does not seem to indicate that we're in big trouble yet -- the vaccines are still effectively preventing death -- but seeing the breakthrough cases gives me pause. I would appreciate if the "establishment" would circle back and address the risk of ADE. Even if it is very unlikely, what is the game plan if new breakthrough strains do start causing this type of response?
Because right now, it seems to me that if humanity puts all its eggs in the vaccine basket, and then ADE occurs with a breakthrough strain, then there is potential for an enormous catastrophe.
[1] https://transcripts.cnn.com/show/sitroom/date/2020-03-26/seg...